Lamin B1 (D4Q4Z) Rabbit mAb 12586S from Cell Signaling Technology

Product Specs
ItemLamin B1 (D4Q4Z) Rabbit mAb
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number12586S
Quantity100 µl
ApplicationsW
ReactivityH, M, R
TargetLamin B1
HostRabbit
NCBI Full Gene Namelamin B1
NCBI Gene AliasesADLD, LMN, LMN2, LMNB, MCPH26
ClonalityMonoclonal
Research AreaApoptosis
CloneD4Q4Z
Molecular Weight68, 25

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Targeting the Endothelin-1 pathway to reduce invasion and chemoresistance in gallbladder cancer cellsCancer Cell IntDecember 10, 2023Francisco Rodas, Jetzabel A. Vidal-Vidal, Daniela Herrera, David A. Brown-Brown, Diego Vera, Joaquín Veliz, Pilar Püschel, José I. Erices, Verónica Sánchez Hinojosa, Julio C. Tapia, et al.Biotechnology #47778, 1:5000), MMP9 (CST #13667, 1:1000), ZEB1 (CST #3396, 1:1000), Lamin B1 (CST #12586, 1:1000), β-catenin (BD Biosciences #610153, 1:1000), NF-kB (CST #6956, 1:1000), ETAR (Thermo Scientific™

(2) Sedanolide Activates KEAP1–NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell DeathInternational Journal of Molecular SciencesNovember 20, 2023Yosuke Tabei, Hiroko Abe, Shingo Suzuki, Nobuaki Takeda, Jun-ichiro Arai, Yoshihiro Nakajima(ProteinSimple Co.). Primary antibodies Nrf2 (#NBP1-32822; Novus Biologicals, Centennial, CO, USA), lamin B1 (#12586; Cell Signaling Technology, Danvers, MA, USA), and GAPDH (#2118; Cell Signaling Technology) were diluted

(3) Death receptor 5 promotes tumor progression in gastric cancerFEBS Open BioNovember 14, 2023Junbing Chen, Lin Li, Longtao Huangfu, Hong Du, Xin Ji, Xiaofang Xing, Jiafu Jiincubated with the following primary antibodies overnight at 4 °C: DR5 (#ab8416, Abcam), Lamin B1 (#12586, Cell Signaling Technologies, Danvers, MA, USA), and β‐actin (sc‐69879, Santa Cruz, Dallas, TX, USA).

(4) CD38/ADP-ribose/TRPM2-mediated nuclear Ca(2+) signaling is essential for hepatic gluconeogenesis in fasting and diabetesExperimental & molecular medicineJuly 1, 2023Rah SY, Joe Y, Park J, Ryter SW, Park C, Chung HT, Kim UH.(Sigma-Aldrich, SAB4300504), Cx43 (Cell Signaling, 3512), Flag (Sigma-Aldrich, F7425), Lamin B1 (Cell Signaling, 12586), PKCδ (Cell Signaling, 9616), TRPM2 (Novus, NB110-81601), Na+K+-ATPase (Novus, NB300-146), Calregulin

(5) Regulation of PD-L1 expression in non–small cell lung cancer by interleukin-1βFrontiers in ImmunologyJune 27, 2023Aiko Hirayama, Kentaro Tanaka, Hirono Tsutsumi, Takayuki Nakanishi, Sho Yamashita, Shun Mizusaki, Yumiko Ishii, Keiichi Ota, Yasuto Yoneshima, Eiji Iwama, et al.(#4668), to JNK (#9252), to phospho-ERK1/2 (#4370), to ERK1/2 (#9102), to IRF1 (#8478), or to lamin B1 (#12586), all of which were obtained from Cell Signaling Technology (CST). The membrane was subsequently incubated

(6) KRT5+/p63+ Stem Cells Undergo Senescence in the Human Lung with Pathological AgingAging and diseaseJune 1, 2023Manuel Moreno-Valladares, Veronica Moncho-Amor, Tulio M Silva, Juan P Garcés, María Álvarez-Satta, Ander Matheu805-4713), p21CIP (Roche Ventana, cat number: 760-4453), Lamin B1 (Cell Signaling Technology, cat number: 12586S; dilution 1:300), Ki67 (Roche Ventana, cat number: 790-4286) and KRT14 (Roche Ventana, cat number: 760-4805).

(7) Tremella fuciformis Polysaccharide Induces Apoptosis of B16 Melanoma Cells via Promoting the M1 Polarization of MacrophagesMoleculesMay 11, 2023Lingna Xie, Guangrong Liu, Zebin Huang, Zhenyuan Zhu, Kaiye Yang, Yiheng Liang, Yani Xu, Lanyue Zhang, Zhiyun Duphospho-p44/42MAPK (9101S), p38 (9212S), phospho-p38 (9211S), NF-κB (8242S), phospho-NF-κB (3033S), lamin B1 (12586S), beta-actin (58169S) were obtained from Cell Signaling Technology (Danvers, MA, USA). The 35 mm confocal

(8) Anti-Atopic Effect of Isatidis Folium Water Extract in TNF-α/IFN-γ-Induced HaCaT Cells and DNCB-Induced Atopic Dermatitis Mouse ModelMoleculesMay 8, 2023Ga-Yul Min, Tae In Kim, Ji-Hye Kim, Won-Kyung Cho, Ju-Hye Yang, Jin Yeul Ma(p-p38 #9211, t-p38 #9212; Cell Signaling Technology, USA) and NF-κB/Lamin B1 (NF-κB #8242, Lamin B1 #12586; Cell Signaling Technology, USA), diluted at 1:1000 in 3% BSA, and incubated overnight at 4 °C, followed

(9) TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signallingJHEP reports : innovation in hepatologyMay 1, 2023Su W, Gao W, Zhang R, Wang Q, Li L, Bu Q, Xu Z, Liu Z, Wang M, Zhu Y, et al.(1:1000, cat# 5174, CST), NRF2 antibody (1:1000, cat# 12721, CST), Lamin B1 antibody (1:1000, cat# 12586, CST), phospho-STAT1 antibody (1:1000, cat# 9167, CST), Arginase-1 (ARG-1) antibody (1:1000, cat# 93668,

(10) New Findings: Hindlimb Unloading Causes Nucleocytoplasmic Ca(2+) Overload and DNA Damage in Skeletal MuscleCellsApril 3, 2023Yang H, Wang H, Pan F, Guo Y, Cao L, Yan W, Gao Y.1,4,5-tetrakisphosphate receptor (IP3R1)","1:1000, ab108517, Abcam, Cambridge, UK" Lamina protein B1 (LaminB1),"1:1000, 12586S, Cell Signaling Technology, Danvers, MA, USA" Na+/Ca2+ exchanger 3 (NCX3),"1:1000, YN1335, Immunoway,

(11) Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrasesNature biotechnologyApril 1, 2023Yarnall MTN, Ioannidi EI, Schmitt-Ulms C, Krajeski RN, Lim J, Villiger L, Zhou W, Jiang K, Garushyants SK, Roberts N, et al.with primary antibodies (β-Actin antibody [4967S] with GAPDH antibody [97166S] or Lamin B1 antibody [12586S] with GAPDH antibody [97166S]) from Cell Signaling Technology. Antibodies were diluted at 1:1,000 in

(12) Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammagingAging CellApril 1, 2023Emin Onur Karakaslar, Neerja Katiyar, Muneer Hasham, Ahrim Youn, Siddhartha Sharma, Cheng‐han Chung, Radu Marches, Ron Korstanje, Jacques Banchereau, Duygu Ucarsecondary antibodies The antibodies of GAPDH (sc‐25778, 1:200, Santa Cruz Biotechnology), Lamin B1 (12586S, 1:100; Cell Signaling Technology), and c‐Jun (9165S, 1:50; Cell Signaling Technology) were diluted

(13) Targeting the NF-κB pathway enhances responsiveness of mammary tumors to JAK inhibitorsScientific ReportsApril 1, 2023Aditi S. Bapat, Christine H. O’Connor, Kathryn L. SchwertfegerCell Signaling #2118), β-tubulin (1:1000, Cell Signaling #2146S), Lamin B1 (1:1000, Cell Signaling #12586S). We detected two bands for total STAT5 proteins, which correspond to Stat5a and STAT5b, isoforms of

(14) Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte HypertrophyCirculation researchMarch 31, 2023Subramaniam G, Schleicher K, Kovanich D, Zerio A, Folkmanaite M, Chao YC, Surdo NC, Koschinski A, Hu J, Scholten A, et al.1:1000; Cell Signaling), HDAC-1 (catalog number 34589, 1:1000; Cell Signaling), lamin B (catalog number 12586, 1:1000; Cell Signaling), lamin A/C (catalog number 4777S, 1:1000; Cell Signaling), actin-1 alpha (catalog

(15) Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesisOncogeneMarch 24, 2023Youjin Na, Ashley Hall, Yanan Yu, Liang Hu, Kwangmin Choi, Jake A. Burgard, Sara Szabo, Gang Huang, Nancy Ratner, Jianqiang Wu(#11815 S), ERK1/2 (#4695 S), p-ERK (#5726 S), CHOP (#5554 S), PARP (9542 S), XPO-1 (#46249), lamin B1 (#12586 S), GAPDH (#3683 S), β-actin (#5125 S) were from Cell Signaling Technology (Danvers, MA), p21 (#sc-6246)

(16) Butein Inhibits Cell Growth by Blocking the IL-6/IL-6Rα Interaction in Human Ovarian Cancer and by Regulation of the IL-6/STAT3/FoxO3a PathwayInternational Journal of Molecular SciencesMarch 23, 2023Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo1:500), anti-STAT3 (cat.no. 12640S; 1:500), anti-FoxO3a (cat. no. 2497S; 1:1000), and Lamin B1 (cat.no. 12586S, 1:1000) (all from Cell Signaling Technologies, Danvers, MA, USA). 4.13. Mouse Xenografts Adult BALB/c

(17) Long Non-Coding RNA Malat1 Increases the Rescuing Effect of Quercetin on TNFα-Impaired Bone Marrow Stem Cell Osteogenesis and Ovariectomy-Induced OsteoporosisInternational Journal of Molecular SciencesMarch 22, 2023Lu Feng, Zhengmeng Yang, Nan Hou, Ming Wang, Xuan Lu, Yucong Li, Haixing Wang, Yaofeng Wang, Shanshan Bai, Xiaoting Zhang, et al.USA), mouse anti-β-actin (1:3000, Sc-8432, Santa Cruz, CA, USA), and rabbit anti-lamin B (1:3000, CST-12586, Cell signaling technology, Danvers, MA, USA) at 4 °C overnight and washed with Tris-buffered saline

(18) TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathwayExperimental & Molecular MedicineMarch 1, 2023Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, et al.D6P2U; CST), anti-C/EBPα (Cat. ab15048; Abcam), anti-tubulin (Cat. 2148; CST), anti-lamin B1 (cat. 12586; CST), and anti-β-actin (Cat. sc-47778; Santa Cruz Biotechnology) antibodies. The signals were quantified

(19) Acenocoumarol Exerts Anti-Inflammatory Activity via the Suppression of NF-κB and MAPK Pathways in RAW 264.7 CellsMoleculesFebruary 22, 2023Hyun-Ju Han, Chang-Gu Hyun(9212S), p-JNK (9251S), JNK (9252S), iNOS (2982S), p-IκBα (9246S), IκBα (4812S), p65 (4764S), lamin B (12586), β-actin (4967S), and secondary anti-mouse and anti-rabbit antibodies were purchased from Cell Signaling Technology

(20) Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver DiseasePharmaceuticals (Basel, Switzerland)December 22, 2022Cheng S, Kuang Y, Li G, Wu J, Ko CN, Wang W, Ma DL, Ye M, Leung CH.China; Cat#: abs137975), or anti-lamin B (1:1000, Cell Signaling Technology, Danvers, MA, USA; Cat # 12586S) overnight. The membranes were washed with wash buffer three times. A secondary antibody (1:1000) was

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Lamin B1 (D4Q4Z) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Lamin B1 (D4Q4Z) Rabbit mAb from Cell Signaling Technology

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